What is Natural Factors Vitamin K2+D3, and what is it used for?
Natural Factors Vitamin K2+D3 is a combination softgel providing 120 mcg of vitamin K2 (as MK-7 from natto fermentation) and 1,000 IU of vitamin D3 (cholecalciferol) per capsule, in a 180-softgel pack — approximately six months of daily supplementation. D3 enhances intestinal calcium absorption while K2 activates proteins that direct calcium to bones and teeth and prevent arterial calcification. The combination addresses a key concern: high-dose D3 without adequate K2 can elevate blood calcium without properly routing it to skeletal tissue.
What are the ingredients in Natural Factors K2+D3 and how do they work together?
Each softgel contains vitamin K2 as menaquinone-7 (MK-7, 120 mcg) from natto fermentation and vitamin D3 as cholecalciferol (1,000 IU) in an MCT oil base from coconut and palm oil to support fat-soluble vitamin absorption. MK-7 activates osteocalcin, which incorporates calcium into bone matrix, and matrix Gla protein (MGP), which prevents calcium from depositing in arterial walls. Excipients include gelatin, glycerine, caramel, beeswax, and soy lecithin. Contains soy-derived ingredients.
Who should take Natural Factors K2+D3, and how is it used?
Suitable for adults with limited sun exposure, low dietary K2, those at risk of bone density loss (especially postmenopausal women), and those already supplementing vitamin D who want calcium directed safely to bone. Take 1 softgel daily with a fat-containing meal to support absorption of these fat-soluble vitamins; pairs well with calcium supplementation. Seek physician guidance during pregnancy or breastfeeding. Those with soy allergies should note the soy lecithin excipient.
What makes Natural Factors K2+D3 different from other K2+D3 products?
The K2 form is MK-7 from natto — not synthetic MK-4. MK-7 has a plasma half-life of approximately 72 hours versus just hours for MK-4, allowing a single 120 mcg daily dose to maintain sustained blood levels that reach arterial walls and bone matrix. MK-4 supplements typically require multi-milligram doses to compensate for rapid clearance. A 2025 meta-analysis published in Frontiers in Nutrition confirmed that regular MK-7 intake elevates serum K2 levels, enhances osteocalcin carboxylation (a direct marker of bone matrix protein activation), and supports bone density. The 180-softgel pack provides approximately six months of supply at a value price for a product using the premium MK-7 form.
What is Natural Factors, and is it a trustworthy supplement brand?
Natural Factors is a Canadian-owned supplement manufacturer founded in 1948 and headquartered in Coquitlam, British Columbia. One of North America's largest supplement makers, it operates over 1,000 acres of certified organic farmland in BC's Okanagan Valley and manufactures in-house at Health Canada-licensed, FDA-inspected facilities. Every product is third-party tested through ISURA for over 800 contaminants including pesticides and heavy metals. Natural Factors is also B Corp certified, meeting rigorous environmental and social standards.
What is Natural Factors and is it a reliable Canadian supplement brand?
Natural Factors is one of Canada's largest supplement manufacturers, founded in 1955 by Jack and Rona Katz in British Columbia and still 100% Canadian family-owned. The company controls every production stage from raw material sourcing to finished product. Its facility holds TGA certification from Australia's Therapeutic Goods Administration, one of the world's strictest supplement manufacturing standards. All products are ISURA certified — independently tested for 800+ contaminants including pesticides and heavy metals — and Natural Factors conducts four rounds of product testing, double the industry average of two.
What sets Natural Factors apart from other supplement brands?
Natural Factors' most distinctive quality is vertical integration: the company grows its own raw herbs on 1,000+ acres of certified organic farmland in BC's Okanagan Valley, then processes and manufactures in-house. Most supplement brands source raw materials from external suppliers with no direct agricultural control. Natural Factors also uses ISURA third-party testing, a Canadian standard that screens for over 800 contaminants, well beyond typical heavy-metal panels. B Corp certification further reflects a documented commitment to environmental and social accountability, not just a marketing claim.
What makes Natural Factors different from other Canadian supplement manufacturers?
Natural Factors holds TGA certification from Australia's Therapeutic Goods Administration — one of the world's most rigorous pharmaceutical manufacturing standards, rarely earned by Canadian brands and far exceeding most North American certification requirements. Its ISURA testing program screens every product for 800+ contaminants, and it conducts four rounds of quality testing per product versus the industry standard of two. The company also operates its own farm in the Okanagan Valley for select botanical ingredients — a level of vertical integration uncommon among supplement manufacturers — and has been family-owned for over 70 years.
The information provided above is for reference purposes only and has not been reviewed or approved by Health Canada. It does not constitute medical advice and should not replace consultation with a qualified healthcare professional.