• Supports healthy gastric acid levels and protein digestion with Betaine HCl + Pepsin, complementing the stomach's natural digestive enzymes.
• Aids protein breakdown into smaller, easily absorbed molecules, enhancing nutrient absorption.
• Helps relieve common symptoms of low stomach acid, such as indigestion, bloating, belching, and heartburn.
• Supports overall digestive health by optimizing the gastric environment, especially with aging or dietary changes.
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Metagenics, SpectraZyme™ Betaine HCI + Pepsin, 90 Capsules
Size
90
tablets
39 people have viewed this item in the last 7 days
About this item
Suggested Use
Adults take 1 tablet 3 times daily with or immediately after meals or as directed by your healthcare practitioner.
Ingredients
Each tablet contains:
Betaine HCl
650
mg
Pepsin (porcine)
45
mg
Non-medical Ingredients:
Cellulose, stearic acid (veg), silicon dioxide, magnesium stearate (veg), and coating (hypromellose, hydroxypropylcellulose, and medium-chain triglycerides).
Description
SpectraZyme® Metagest— features betaine HCl combined with pepsin — a proteolytic enzyme — to complement the natural production of digestive agents in the stomach.
Frequently Asked Questions
What is Metagenics Spectrazyme Betaine HCl Pepsin, and what is it used for?
A 90-tablet supplement providing 650 mg of betaine hydrochloride (HCl) and 45 mg of pepsin per tablet, taken 3 tablets daily with or immediately after meals. Designed to address hypochlorhydria — insufficient stomach acid production — by supplementing gastric acid and the protein-digesting enzyme pepsin simultaneously. Supports protein digestion, nutrient absorption, and relief of indigestion, bloating, belching, and heartburn caused by low gastric acid rather than excess acid.
How do betaine HCl and pepsin work together in this formula?
Betaine HCl temporarily restores gastric acidity when stomach acid production is insufficient. A clinical study found that 1,500 mg betaine HCl lowered stomach pH from 5.2 to 0.6 within 30 minutes. This matters because pepsin — the stomach's primary protein-digesting enzyme — is only activated and functional below pH 4; without adequate acid, pepsin cannot digest protein effectively. By providing both the acid environment (betaine HCl) and the enzyme (pepsin 45 mg) in each tablet, the formula addresses hypochlorhydria at two levels simultaneously. Adequate stomach acid also enables absorption of vitamin B12, iron, calcium, magnesium, and zinc.
Who should take Metagenics Spectrazyme Betaine HCl Pepsin, and how is it used?
For adults experiencing digestive discomfort, bloating, belching, or heartburn that may stem from insufficient stomach acid — particularly older adults (gastric acid production naturally declines with age), those on long-term PPI or antacid therapy, and those with autoimmune gastritis. Take 1 tablet 3 times daily with or immediately after each main meal. Do not use if pregnant or breastfeeding, or if you have gastric ulcers, excess stomach acid, high cholesterol, or are taking blood thinners or anti-inflammatory drugs. Stop use if allergic reaction occurs. Do not refrigerate.
How is Spectrazyme Betaine HCl Pepsin different from standard digestive enzymes or antacids?
This product addresses the opposite problem from antacids: rather than neutralizing excess acid, it supplements insufficient acid — a critical distinction. Many people with heartburn and indigestion actually have too little stomach acid (hypochlorhydria), not too much; antacids worsen this underlying deficiency. Betaine HCl plus pepsin is the standard clinical protocol for hypochlorhydria management in integrative medicine. The 650 mg betaine HCl per tablet is among the higher per-tablet doses available, meaningful because therapeutic loading typically requires matching the clinical dose range of 1,500-3,000 mg per meal. Pepsin is specifically paired because it functions only at low pH — delivering both the acid and the enzyme together in one tablet that dissolves at mealtime is the correct clinical approach. Metagenics TruQuality lot-traceable quality allows batch-level verification of testing results.
What is Metagenics and who are its supplements designed for?
Metagenics is an American functional medicine supplement brand founded in 1983 by Dr. Jeffrey Bland, widely regarded as the father of functional medicine. Products address root causes of chronic illness rather than symptoms, targeting gut health, hormonal balance, detoxification, cardiometabolic health, and cognitive function. Manufacturing is USP GMP and NSF GMP certified, with over 60,000 quality control tests conducted annually. Metagenics is the number-one doctor-recommended professional supplement brand in North America and holds Certified B Corp status. Products are available through licensed healthcare practitioners.
What is Metagenics and are its supplements safe to use in Canada?
Metagenics is a science-based supplement brand founded in 1983, with Canadian operations headquartered in Mississauga, Ontario. All Metagenics products sold in Canada carry Health Canada Natural Product Numbers (NPN), confirming they have been reviewed for safety, efficacy, and quality under Canada's Natural Health Products Regulations. Manufacturing facilities are audited by USP GMP, NSF International GMP, and Canada's Natural and Non-Prescription Health Products Directorate (NNHPD). Metagenics is also a certified B Corporation (since 2022) and offers lot-level quality transparency through its TruQuality® Guarantee, allowing customers to verify testing results for every formula by lot number.
How is Metagenics different from regular supplement brands sold in stores?
Metagenics differs from typical retail supplements in three ways. First, it is a practitioner-grade brand — formulated for therapeutic use and traditionally distributed through licensed healthcare providers, not mass retail, making it the #1 Doctor Recommended Professional Supplement Brand in North America. Second, its formulas are built on nutrigenomics research — the science of how nutrition interacts with genes — backed by hundreds of clinical studies, with a focus on bioavailability-optimized ingredient forms rather than generic powders. Third, it maintains multi-layer independent quality verification: USP GMP, NSF GMP, and NNHPD Canada audits, with every formula's testing results accessible online by lot number via the TruQuality® Guarantee.
What makes Metagenics different from other professional-grade supplement brands?
Metagenics was built around nutrigenomics — the science of how nutrients regulate gene expression — a field its founder Dr. Jeffrey Bland helped pioneer before it was mainstream. This underpins formulas designed to modulate biological pathways at the cellular level, not just correct deficiencies. Unlike brands that adopted practitioner distribution as a later marketing channel, Metagenics was practitioner-exclusive from inception, with clinical protocols as the core of product design. It has participated in hundreds of clinical trials and conducts over 60,000 quality control tests annually — a depth of evidence unusual for the supplement category.
How Metagenics products tested for quality and safety?
Every Metagenics product undergoes rigorous testing at every stage of production, including raw ingredients, finished formulas, and final encapsulation. We don’t just meet industry standards—we exceed them.
While the FDA requires minimal oversight for supplements, we invest over $1.5 million annually into quality assurance. That includes nearly 50,000 tests per year conducted by more than 70 global quality experts to ensure purity, safety, and potency.
Each product is triple-tested for identity, strength, and consistency—so what’s on the label is exactly what’s in the bottle. And to hold ourselves to an even higher standard, we also voluntarily submit every product for third-party testing to confirm quality and transparency you can trust.
While the FDA requires minimal oversight for supplements, we invest over $1.5 million annually into quality assurance. That includes nearly 50,000 tests per year conducted by more than 70 global quality experts to ensure purity, safety, and potency.
Each product is triple-tested for identity, strength, and consistency—so what’s on the label is exactly what’s in the bottle. And to hold ourselves to an even higher standard, we also voluntarily submit every product for third-party testing to confirm quality and transparency you can trust.
The information provided above is for reference purposes only and has not been reviewed or approved by Health Canada. It does not constitute medical advice and should not replace consultation with a qualified healthcare professional.
Caution
Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, have excessive stomach acid, have high cholesterol or a peptic ulcer. Consult a healthcare practitioner prior to use if you have gastrointestinal lesions/ulcers, are taking blood thinners or anti-inflammatory agents, or are having surgery. Stop use if hypersensitivity (e.g. allergy) occurs. For prolonged use, consult a health care practitioner. Do not refrigerate. Do not use if perma seal is missing.
Disclaimer
You should not use the information or services on this Site to diagnose or treat any health issues or for prescription of any medication or other treatment.
Always check the product label or packaging prior to using any product. If there are discrepancies, customers should follow the information provided on the product label or packaging.
Metagenics, SpectraZyme™ Betaine HCI + Pepsin, 90 Capsules
Size
90
tablets
39 people have viewed this item in the last 7 days
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