Metagenics, OmegaGenics EPA-DHA 1000, 120 Softgels

Metagenics OmegaGenics EPA-DHA 1000 is a practitioner-grade high-potency combined omega-3 fish oil supplement providing EPA 710 mg and DHA 290 mg per softgel (total omega-3 1,000 mg) from sustainably sourced cold-water fish (mackerel, sardine, anchovy), within a 1,400 mg fish oil base. It is formulated in triglyceride form for superior absorption compared to the ethyl ester form used in many commercial fish oils. It is used to support cardiovascular health and help lower serum triglycerides, support cognitive health and healthy mood balance, and -- combined with conventional therapy -- help reduce pain associated with rheumatoid arthritis. Health Canada has issued NPN 80054489.

Each softgel provides fish oil 1,400 mg from mackerel, sardine, and anchovy, yielding EPA 710 mg and DHA 290 mg. Non-medicinal ingredients: gelatin, glycerin, purified water, natural lemon flavor (2% or less), mixed tocopherols, rosemary extract, ascorbyl palmitate. The last three non-medicinal ingredients are antioxidant stabilizers: mixed tocopherols (vitamin E), rosemary extract (containing carnosic acid and rosmarinic acid), and ascorbyl palmitate (fat-soluble vitamin C ester) -- this triple antioxidant system protects the omega-3 fatty acids from oxidation during storage and shelf life more comprehensively than the single tocopherol stabilizer used in many fish oil products. The triglyceride form is a meaningful formulation distinction: most concentrated fish oils are processed into ethyl ester (EE) form to reach high omega-3 concentrations, but re-esterified triglyceride (rTG) form more closely resembles the natural molecular structure of omega-3s in fish tissue. Comparative absorption studies show rTG fish oil achieves approximately 70% greater bioavailability than EE form, because pancreatic lipase (the enzyme that breaks down dietary fats for absorption) cleaves triglycerides efficiently but processes ethyl esters significantly more slowly and less completely. The result is more omega-3 absorbed per capsule taken.

OmegaGenics EPA-DHA 1000 is appropriate for adults seeking high-dose combined omega-3 support across cardiovascular, cognitive, and inflammatory health applications. The combined EPA+DHA profile makes it versatile compared to EPA-only products: DHA is essential for brain and retinal membrane structure and is the primary omega-3 for cognitive and mood support, while EPA drives the anti-inflammatory eicosanoid pathways and triglyceride reduction. Together at 1,000 mg omega-3 per softgel, the daily dose of 3 softgels provides EPA 2,130 mg and DHA 870 mg -- a total of 3,000 mg of combined omega-3, which is within the range used in clinical trials for triglyceride reduction, cardiovascular risk management, and inflammatory conditions. This product is particularly suitable for: adults with elevated triglycerides or cardiovascular risk; people with mood disorders, depression, or cognitive concerns where DHA brain support is relevant; individuals with rheumatoid arthritis using omega-3 as a complement to conventional treatment; and anyone requiring high-dose omega-3 support who prefers a combined product. Recommended dose: adults 1 softgel 3 times daily (with each meal), or as directed by a healthcare practitioner. Consult a physician if taking anticoagulants; discontinue 2 weeks before surgery.

Four verifiable distinctions. First, triglyceride form: as noted, rTG form achieves approximately 70% greater bioavailability than ethyl ester form in comparative studies. Most mass-market high-dose fish oil supplements use the cheaper ethyl ester form; Metagenics uses re-esterified triglyceride to maximize absorption per capsule. Second, omega-3 concentration per softgel: at 710 mg EPA + 290 mg DHA = 1,000 mg omega-3 per 1,400 mg softgel, the omega-3 concentration is 71% -- higher than standard fish oil concentrates (typically 60-65%) and comparable to premium pharmaceutical-grade fish oils. Third, triple antioxidant stabilization: the combination of mixed tocopherols, rosemary extract, and ascorbyl palmitate protects against oxidative rancidity more comprehensively than single-antioxidant systems -- oxidized fish oil is not only less potent but may be pro-inflammatory, making oil freshness a genuine quality consideration. Fourth, dual GMP certification and TruQuality traceability: USP GMP and NSF International GMP certifications plus online batch traceability (each lot's testing data is accessible by lot number) provide independent verification of purity and potency at a level rare in the supplement category. Metagenics distributes through healthcare practitioners, and the 120-softgel bottle at 3 softgels/day provides a 40-day supply.

Metagenics is an American functional medicine supplement brand founded in 1983 by Dr. Jeffrey Bland, widely regarded as the father of functional medicine. Products address root causes of chronic illness rather than symptoms, targeting gut health, hormonal balance, detoxification, cardiometabolic health, and cognitive function. Manufacturing is USP GMP and NSF GMP certified, with over 60,000 quality control tests conducted annually. Metagenics is the number-one doctor-recommended professional supplement brand in North America and holds Certified B Corp status. Products are available through licensed healthcare practitioners.

Metagenics is a science-based supplement brand founded in 1983, with Canadian operations headquartered in Mississauga, Ontario. All Metagenics products sold in Canada carry Health Canada Natural Product Numbers (NPN), confirming they have been reviewed for safety, efficacy, and quality under Canada's Natural Health Products Regulations. Manufacturing facilities are audited by USP GMP, NSF International GMP, and Canada's Natural and Non-Prescription Health Products Directorate (NNHPD). Metagenics is also a certified B Corporation (since 2022) and offers lot-level quality transparency through its TruQuality® Guarantee, allowing customers to verify testing results for every formula by lot number.

Metagenics differs from typical retail supplements in three ways. First, it is a practitioner-grade brand — formulated for therapeutic use and traditionally distributed through licensed healthcare providers, not mass retail, making it the #1 Doctor Recommended Professional Supplement Brand in North America. Second, its formulas are built on nutrigenomics research — the science of how nutrition interacts with genes — backed by hundreds of clinical studies, with a focus on bioavailability-optimized ingredient forms rather than generic powders. Third, it maintains multi-layer independent quality verification: USP GMP, NSF GMP, and NNHPD Canada audits, with every formula's testing results accessible online by lot number via the TruQuality® Guarantee.

Metagenics was built around nutrigenomics — the science of how nutrients regulate gene expression — a field its founder Dr. Jeffrey Bland helped pioneer before it was mainstream. This underpins formulas designed to modulate biological pathways at the cellular level, not just correct deficiencies. Unlike brands that adopted practitioner distribution as a later marketing channel, Metagenics was practitioner-exclusive from inception, with clinical protocols as the core of product design. It has participated in hundreds of clinical trials and conducts over 60,000 quality control tests annually — a depth of evidence unusual for the supplement category.

Every Metagenics product undergoes rigorous testing at every stage of production, including raw ingredients, finished formulas, and final encapsulation. We don’t just meet industry standards—we exceed them.

While the FDA requires minimal oversight for supplements, we invest over $1.5 million annually into quality assurance. That includes nearly 50,000 tests per year conducted by more than 70 global quality experts to ensure purity, safety, and potency.

Each product is triple-tested for identity, strength, and consistency—so what’s on the label is exactly what’s in the bottle. And to hold ourselves to an even higher standard, we also voluntarily submit every product for third-party testing to confirm quality and transparency you can trust.