• Contains BioPQQ® (pyrroloquinoline quinone) disodium salt at 20 mg per capsule — a patented, highly absorbable form used in human trials to support short-term memory, attention, energy metabolism, and overall well-being.
• Supports mitochondrial health and cellular energy by reducing mitochondrial oxidative stress and promoting mitochondrial biogenesis, helping counter age-related energy decline.
• Provides neuroprotective support by promoting nerve growth factor (NGF) production and helping shield neurons from oxidative damage and excitotoxicity.
• Quality and safety: BioPQQ is produced via patented natural fermentation, the PQQ used in clinical trials, with FDA NDI notification and GRAS status, offering a trusted option for heart and brain health.
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Natural Factors, Bio-PQQ, Pyrroloquinoline Quinone, 20mg, 30 VCaps
Size
30
vegetarian capsules
UPC
068958026077
Best Before
12/2029
67 people have viewed this item in the last 7 days
About this item
Suggested Use
Recommended adult dose: 1 capsule daily with food or as directed by a health care practitioner.
Ingredients
Each vegetarian capsule contains:
BioPQQ® (pyrroloquinoline quinone disodium salt)
20
mg
--Providing pyrroloquinoline quinone
17.65
mg
Non-medical Ingredients:
Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant).
Description
Pyrroloquinoline quinone (PQQ) is a recently discovered vitamin-like compound with antioxidant and B-vitamin-like activity that has a wide range of benefits for brain and body function. Clinical studies in humans have shown that PQQ enhances short-term memory and attention, improves energy metabolism, and reduces markers of inflammation, as well as improving general feelings of well-being.
PQQ is known to influence multiple cellular pathways, including the production of nerve growth factor (NGF). Like CoQ10, PQQ has diverse benefits for mitochondrial function. It has been shown to attenuate mitochondrial oxidative stress as well as stimulate mitochondrial biogenesis. Mitochondrial dysfunction is a key factor in the development of numerous health conditions, especially those typically related to aging.
PQQ not only supports cellular energy, but has neuroprotective properties. It protects cognitive health by promoting the recovery of damaged nerves, protecting neurons against oxidative damage and toxicity (including glutamate-induced toxicity), and helping combat the degenerative changes common to many neurodegenerative diseases.
BioPQQ is created using a patented natural fermentation process that results in a highly absorbable PQQ disodium salt. BioPQQ is the type of PQQ used in successful human clinical trials. BioPQQ is an innovative way to support energy levels, cardiovascular health, and cognitive function, as well as protect against age-related cognitive decline.
Frequently Asked Questions
What is Natural Factors BioPQQ, and what does PQQ do in the body?
Natural Factors BioPQQ provides 20 mg of BioPQQ per vegetarian capsule — a patented form of Pyrroloquinoline Quinone (PQQ), a redox cofactor naturally found in vegetables and human breast milk. PQQ acts as a potent antioxidant and B-vitamin-like cofactor that supports broad brain and body function. Clinical studies show that PQQ supplementation enhances short-term memory and attention, improves energy metabolism, reduces inflammatory markers, and supports overall sense of wellbeing. BioPQQ also plays a key role in mitochondrial health by reducing oxidative stress within mitochondria and stimulating the growth of new mitochondria — a process called mitochondrial biogenesis that becomes increasingly important with age.
How does BioPQQ support cognitive function and mitochondrial health, and what does the clinical evidence show?
BioPQQ supports cognition and energy through two complementary pathways. First, it stimulates nerve growth factor (NGF) production and protects neurons from oxidative damage and glutamate-induced toxicity, which may help counter the neurodegeneration seen in cognitive decline. Second, it reduces mitochondrial oxidative stress and promotes mitochondrial biogenesis — the creation of new mitochondria — which is one of the primary drivers of age-related energy loss. Clinical trials using BioPQQ specifically show that 8 weeks of supplementation reduces cognitive confusion, anxiety, and low mood while improving energy levels. At 24 weeks, improvements in memory and spatial awareness are observed. Each capsule provides 20 mg BioPQQ (containing 17.65 mg active PQQ disodium salt), the dose used in human trials.
Who should consider taking BioPQQ, and how should it be used?
BioPQQ is well-suited for adults experiencing age-related cognitive changes or energy decline — particularly those aged 40 and above noticing memory lapses, reduced mental clarity, or fatigue that does not resolve with rest. It is also appropriate for individuals seeking to support mitochondrial function as part of a broader longevity or anti-aging supplement regimen, and for people who want neuroprotective support without stimulant effects. The recommended adult dose is one capsule daily with a meal. PQQ pairs well with CoQ10 for synergistic mitochondrial and cardiovascular support. Consult a healthcare professional before use if pregnant or breastfeeding.
What distinguishes BioPQQ from other PQQ supplements on the market?
BioPQQ is the only PQQ form to have received both FDA New Dietary Ingredient (NDI) notification and Generally Recognized As Safe (GRAS) designation, confirming that the U.S. FDA has reviewed and accepted the safety data for this specific ingredient. This regulatory recognition is not held by generic PQQ ingredients. BioPQQ is also the PQQ form used in published human clinical trials, which means the cognitive and energy benefits cited in research apply directly to this product — not to structurally similar but untested alternatives. Natural Factors' version further benefits from ISURA third-party testing for 800+ contaminants and four rounds of product quality verification, double the industry standard. The excipient profile is minimal: microcrystalline cellulose, vegetable capsule, and plant-sourced magnesium stearate — no unnecessary fillers.
What is Natural Factors, and is it a trustworthy supplement brand?
Natural Factors is a Canadian-owned supplement manufacturer founded in 1948 and headquartered in Coquitlam, British Columbia. One of North America's largest supplement makers, it operates over 1,000 acres of certified organic farmland in BC's Okanagan Valley and manufactures in-house at Health Canada-licensed, FDA-inspected facilities. Every product is third-party tested through ISURA for over 800 contaminants including pesticides and heavy metals. Natural Factors is also B Corp certified, meeting rigorous environmental and social standards.
What is Natural Factors and is it a reliable Canadian supplement brand?
Natural Factors is one of Canada's largest supplement manufacturers, founded in 1955 by Jack and Rona Katz in British Columbia and still 100% Canadian family-owned. The company controls every production stage from raw material sourcing to finished product. Its facility holds TGA certification from Australia's Therapeutic Goods Administration, one of the world's strictest supplement manufacturing standards. All products are ISURA certified — independently tested for 800+ contaminants including pesticides and heavy metals — and Natural Factors conducts four rounds of product testing, double the industry average of two.
What sets Natural Factors apart from other supplement brands?
Natural Factors' most distinctive quality is vertical integration: the company grows its own raw herbs on 1,000+ acres of certified organic farmland in BC's Okanagan Valley, then processes and manufactures in-house. Most supplement brands source raw materials from external suppliers with no direct agricultural control. Natural Factors also uses ISURA third-party testing, a Canadian standard that screens for over 800 contaminants, well beyond typical heavy-metal panels. B Corp certification further reflects a documented commitment to environmental and social accountability, not just a marketing claim.
What makes Natural Factors different from other Canadian supplement manufacturers?
Natural Factors holds TGA certification from Australia's Therapeutic Goods Administration — one of the world's most rigorous pharmaceutical manufacturing standards, rarely earned by Canadian brands and far exceeding most North American certification requirements. Its ISURA testing program screens every product for 800+ contaminants, and it conducts four rounds of quality testing per product versus the industry standard of two. The company also operates its own farm in the Okanagan Valley for select botanical ingredients — a level of vertical integration uncommon among supplement manufacturers — and has been family-owned for over 70 years.
The information provided above is for reference purposes only and has not been reviewed or approved by Health Canada. It does not constitute medical advice and should not replace consultation with a qualified healthcare professional.
Caution
Consult a health care practitioner prior to use if you are pregnant or breast-feeding. Keep out of the reach of children.
Disclaimer
You should not use the information or services on this Site to diagnose or treat any health issues or for prescription of any medication or other treatment.
Always check the product label or packaging prior to using any product. If there are discrepancies, customers should follow the information provided on the product label or packaging.
Natural Factors, Bio-PQQ, Pyrroloquinoline Quinone, 20mg, 30 VCaps
Size
30
vegetarian capsules
UPC
068958026077
Best Before
12/2029
67 people have viewed this item in the last 7 days
$29.99
Quantity
Not enough inventory in stock
Purchase limit exceeded
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In stock at LIFEPLUS Natural Health
#1825 - 4720 Mcclelland Rd, Richmond, BC
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