• 50 mg of highly bioavailable riboflavin 5’-phosphate sodium (R5P) in a ready-to-use coenzyme form for direct absorption and riboflavin deficiency prevention, enhanced with Farm Fresh Factors phytonutrients.
• Biocoenzymated EnviroSimplex technology delivers the most metabolically active vitamin B2 by pairing the R5P coenzyme with Farm Fresh Factors' organic land-and-sea plant blends.
• Supports energy metabolism, tissue formation, red blood cell and hormone synthesis, and helps activate other B vitamins (folate, B6) while aiding tryptophan to niacin conversion.
• Ideal for those with GI absorption issues or genetic variations that limit standard riboflavin use, providing ready-to-use R5P for improved uptake.
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Natural Factors, BioCoenzymated Riboflavin 5’-Phosphate B2, 50mg, 30 Vcaps
Size
30
vegetarian capsules
UPC
068958012490
25 people have viewed this item in the last 7 days
About this item
Suggested Use
Recommended adult dose: 1 capsule daily or as directed by a health care practitioner .
Ingredients
Each vegetarian capsule contains:
Vitamin B2 (riboflavin 5’-phosphate sodium)
50
mg
Non-medical Ingredients:
Lactose, microcrystalline cellulose, croscarmellose sodium,*Farm Fresh FactorsTM, vegetable grade magnesium stearate (lubricant).
*Active Vegetables – organic kale, organic alfalfa, organic cilantro leaf, organic parsley, caperberry, sprouted garlic, organic artichoke,organic black radish, organic dandelion, barleygrass, pepper, organic celery seed,organic beetroot, organic tomato; Cruciferous Vegetables – A broad spectrum of fully active glucosinolates and myrosinase enzymes from wasabi rhizome (Wasabia japonica) and fresh freeze-dried sprouted broccoli, organic upland cress, daikon, red radish, organic cauliflower,organic cabbage, organic arugula, organic watercress leaf; Ultra Fruit Polyphenols – grape, pomegranate, strawberry, organic blueberry, raspberry, bilberry, organic Indian gooseberry, schizandra berry, red orange, organic acai berry; Herbals and Plants – Theracurmin® curcumin, organic decaffeinated green tea extract, organic ginger rhizome,organic echinacea, organic oregano, organic peppermint,organic spearmint; Whole Plant Sea Vegetables – organic spirulina, organic chlorella, red algae, blue green algae, kelp.
*Active Vegetables – organic kale, organic alfalfa, organic cilantro leaf, organic parsley, caperberry, sprouted garlic, organic artichoke,organic black radish, organic dandelion, barleygrass, pepper, organic celery seed,organic beetroot, organic tomato; Cruciferous Vegetables – A broad spectrum of fully active glucosinolates and myrosinase enzymes from wasabi rhizome (Wasabia japonica) and fresh freeze-dried sprouted broccoli, organic upland cress, daikon, red radish, organic cauliflower,organic cabbage, organic arugula, organic watercress leaf; Ultra Fruit Polyphenols – grape, pomegranate, strawberry, organic blueberry, raspberry, bilberry, organic Indian gooseberry, schizandra berry, red orange, organic acai berry; Herbals and Plants – Theracurmin® curcumin, organic decaffeinated green tea extract, organic ginger rhizome,organic echinacea, organic oregano, organic peppermint,organic spearmint; Whole Plant Sea Vegetables – organic spirulina, organic chlorella, red algae, blue green algae, kelp.
Description
Natural Factors Riboflavin 5’-phosphate represents the next generation of nutritional supplements, providing 50 mg of highly bioavailable coenzymated vitamin B2 as riboflavin 5’-phosphate sodium (R5P) to help prevent riboflavin deficiency, alongside Farm Fresh Factors®, a bioactive blend of phytonutrients. This BioCoenzymated™ supplement is ideal for anyone looking to upgrade from standard vitamin B2 to the most advanced vitamin B2 available.
Vitamin B2 is vital for energy metabolism, tissue formation, red blood cell and hormone synthesis, and to help maintain normal glucose and lipid (fat) metabolism. It is also needed to activate other B vitamins, including folate and vitamin B6, and to convert tryptophan to niacin (vitamin B3).
Research has shown that upper gastrointestinal tract problems and genetic variations can decrease the conversion of standard riboflavin into active R5P, while certain medications can compromise absorption and deplete vitamin B2.
This unique biocoenzymated formula features proprietary EnviroSimplex® technology, combining Farm Fresh Factors, an organic whole food blend of land and sea vegetables, with the coenzyme form of vitamin B2. The result is a synergistic phytochemical formula that delivers the most metabolically active nutrients to your cells. Ready-to-use R5P offers immediate and direct nutritional support.
- Supports the metabolism of carbohydrates, fats, and proteins
- Helps prevent riboflavin deficiency
- Helps in tissue formation
- A factor in the maintenance of good health
Frequently Asked Questions
What is Natural Factors BioCoenzymated R5P B2, and why does the form of vitamin B2 matter?
Natural Factors BioCoenzymated R5P B2 provides 50 mg of riboflavin-5'-phosphate sodium (R5P) per vegetarian capsule — the active coenzyme form of vitamin B2 that the body uses directly at the cellular level without requiring enzymatic conversion. Standard vitamin B2 supplements provide riboflavin in its unconverted form; to become metabolically active, riboflavin must first be phosphorylated in the intestinal wall and liver to become R5P (flavin mononucleotide) and then FAD (flavin adenine dinucleotide). In individuals with impaired upper gastrointestinal absorption, genetic polymorphisms affecting riboflavin kinase activity, or those taking medications that interfere with B2 absorption or metabolism, this conversion step is compromised — meaning standard riboflavin supplements may not deliver effective cellular B2 despite adequate dosing. R5P bypasses this conversion entirely, delivering the metabolically ready coenzyme form directly. The formula also includes Natural Factors' proprietary Farm Fresh Factors blend — a concentrated extract of land and sea vegetables — providing phytonutrient co-factors that enhance the bioavailability and synergistic action of the R5P.
What functions does vitamin B2 (riboflavin) serve in the body, and who is most likely to be deficient?
Riboflavin (vitamin B2) functions as the core component of two essential coenzymes — flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) — that participate in over 200 enzymatic reactions in cellular metabolism. Its most critical roles include: energy metabolism through the electron transport chain in mitochondria (directly involved in ATP production from carbohydrates, fats, and protein); activation of other B vitamins — vitamin B6, folate, and niacin all require riboflavin for conversion to their active forms; red blood cell production and hemoglobin synthesis; tissue formation and maintenance (riboflavin deficiency causes cracking at the corners of the mouth and skin lesions); hormone synthesis including steroids and thyroid hormone; and conversion of tryptophan to niacin. Groups at elevated risk of riboflavin inadequacy include strict vegans and vegetarians (dairy and meat are primary sources), endurance athletes (riboflavin demand increases with exercise intensity), individuals with hypothyroidism or adrenal insufficiency (which impairs riboflavin metabolism), those taking tricyclic antidepressants, phenobarbital, or certain chemotherapy agents, and people with chronic digestive conditions such as Crohn's disease or celiac disease that impair intestinal absorption.
Who should take R5P B2, and how is it used?
BioCoenzymated R5P B2 is most appropriate for adults who have reason to believe their standard riboflavin intake is not being efficiently converted to the active coenzyme form — including those with MTHFR gene variants or other relevant genetic polymorphisms, individuals with impaired gastric or intestinal absorption, those recovering from illness or managing chronic conditions that increase B vitamin demand, people following plant-based diets without reliable riboflavin sources, and anyone taking medications known to interfere with riboflavin metabolism. The recommended dose is one vegetarian capsule per day. As a water-soluble vitamin, riboflavin excess is excreted in urine and does not accumulate to toxic levels in the body, making it safe for ongoing daily supplementation. Pregnant and breastfeeding women should consult a physician before use. The capsule is gluten-free, non-GMO, and vegan.
How does R5P B2 differ from standard riboflavin supplements, and what is the BioCoenzymated system?
Standard riboflavin supplements are sold in the unconverted form and priced as commodity vitamin ingredients, typically costing significantly less than R5P. The case for R5P is based on conversion efficiency: for individuals whose riboflavin-to-R5P conversion is impaired, standard supplements are largely wasted. For those without conversion issues, the difference is smaller but the direct-delivery advantage still applies in terms of speed and certainty of cellular availability. The BioCoenzymated product line from Natural Factors is specifically designed around this principle of pre-converted, metabolically ready nutrients — the series includes B6 as pyridoxal-5'-phosphate (P5P), folate as 5-methyltetrahydrofolate (5-MTHF), and B12 as methylcobalamin, all of which follow the same logic of bypassing enzymatic conversion steps. The EnviroSimplex technology used in this product embeds the R5P within a matrix of concentrated vegetable and plant phytonutrients (the Farm Fresh Factors blend) that serve as natural cofactors, potentially enhancing both absorption and cellular utilization relative to isolated R5P in an inert capsule matrix. The product is validated through Natural Factors' ISURA third-party testing for contaminants and verified for labeled R5P content.
What is Natural Factors, and is it a trustworthy supplement brand?
Natural Factors is a Canadian-owned supplement manufacturer founded in 1948 and headquartered in Coquitlam, British Columbia. One of North America's largest supplement makers, it operates over 1,000 acres of certified organic farmland in BC's Okanagan Valley and manufactures in-house at Health Canada-licensed, FDA-inspected facilities. Every product is third-party tested through ISURA for over 800 contaminants including pesticides and heavy metals. Natural Factors is also B Corp certified, meeting rigorous environmental and social standards.
What is Natural Factors and is it a reliable Canadian supplement brand?
Natural Factors is one of Canada's largest supplement manufacturers, founded in 1955 by Jack and Rona Katz in British Columbia and still 100% Canadian family-owned. The company controls every production stage from raw material sourcing to finished product. Its facility holds TGA certification from Australia's Therapeutic Goods Administration, one of the world's strictest supplement manufacturing standards. All products are ISURA certified — independently tested for 800+ contaminants including pesticides and heavy metals — and Natural Factors conducts four rounds of product testing, double the industry average of two.
What sets Natural Factors apart from other supplement brands?
Natural Factors' most distinctive quality is vertical integration: the company grows its own raw herbs on 1,000+ acres of certified organic farmland in BC's Okanagan Valley, then processes and manufactures in-house. Most supplement brands source raw materials from external suppliers with no direct agricultural control. Natural Factors also uses ISURA third-party testing, a Canadian standard that screens for over 800 contaminants, well beyond typical heavy-metal panels. B Corp certification further reflects a documented commitment to environmental and social accountability, not just a marketing claim.
What makes Natural Factors different from other Canadian supplement manufacturers?
Natural Factors holds TGA certification from Australia's Therapeutic Goods Administration — one of the world's most rigorous pharmaceutical manufacturing standards, rarely earned by Canadian brands and far exceeding most North American certification requirements. Its ISURA testing program screens every product for 800+ contaminants, and it conducts four rounds of quality testing per product versus the industry standard of two. The company also operates its own farm in the Okanagan Valley for select botanical ingredients — a level of vertical integration uncommon among supplement manufacturers — and has been family-owned for over 70 years.
The information provided above is for reference purposes only and has not been reviewed or approved by Health Canada. It does not constitute medical advice and should not replace consultation with a qualified healthcare professional.
Caution
This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
You should not use the information or services on this Site to diagnose or treat any health issues or for prescription of any medication or other treatment.
Always check the product label or packaging prior to using any product. If there are discrepancies, customers should follow the information provided on the product label or packaging.
Natural Factors, BioCoenzymated Riboflavin 5’-Phosphate B2, 50mg, 30 Vcaps
Size
30
vegetarian capsules
UPC
068958012490
25 people have viewed this item in the last 7 days
$9.99
Quantity
Not enough inventory in stock
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In stock at LIFEPLUS Natural Health
#1825 - 4720 Mcclelland Rd, Richmond, BC
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