• Promotes healthy estrogen metabolism by guiding estrogen toward the protective 2-hydroxyestrone metabolite.
• Contains indole-3-carbinol (I-3-C) from cruciferous vegetables, paired with rosemary leaf extract for antioxidant support (I-3-C per capsule: 150 mg; rosemary extract 50 mg; 9:1 equivalent to 450 mg rosemary).
• Nature-identical I-3-C provides a safe, targeted approach to estrogen metabolism.
• 180 capsules provide a convenient long-term supply for ongoing estrogen balance support.
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Metagenics, Indole-3-Carbinol, 180 Capsules
Size
180
capsules
UPC
755571913074
16 people have viewed this item in the last 7 days
About this item
Suggested Use
Adults take 1 capsule twice daily or as directed by your healthcare practitioner.
Ingredients
Each capsule contains:
Indole-3-Carbinol
150
mg
Rosemary (Rosmarinus officinalis L.) 9:1 leaf extract equivalent to 450 mg of rosemary
50
mg
Non-medical Ingredients:
Hypromellose, maltodextrin, magnesium stearate (veg), and silicon dioxide.
Description
Indole-3-Carbinol is designed to promote healthy estrogen metabolism and balance by featuring indole-3-carbinol (I3C), a nature-identical version of the compound found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage.
Through its ability to promote the breakdown of estrogen to its beneficial, protective metabolite—2-hydroxyestrone— indole-3-carbinol may be a safe and effective way to help achieve beneficial balance in estrogen metabolism.
Frequently Asked Questions
What is Metagenics and who are its supplements designed for?
Metagenics is an American functional medicine supplement brand founded in 1983 by Dr. Jeffrey Bland, widely regarded as the father of functional medicine. Products address root causes of chronic illness rather than symptoms, targeting gut health, hormonal balance, detoxification, cardiometabolic health, and cognitive function. Manufacturing is USP GMP and NSF GMP certified, with over 60,000 quality control tests conducted annually. Metagenics is the number-one doctor-recommended professional supplement brand in North America and holds Certified B Corp status. Products are available through licensed healthcare practitioners.
What is Metagenics and are its supplements safe to use in Canada?
Metagenics is a science-based supplement brand founded in 1983, with Canadian operations headquartered in Mississauga, Ontario. All Metagenics products sold in Canada carry Health Canada Natural Product Numbers (NPN), confirming they have been reviewed for safety, efficacy, and quality under Canada's Natural Health Products Regulations. Manufacturing facilities are audited by USP GMP, NSF International GMP, and Canada's Natural and Non-Prescription Health Products Directorate (NNHPD). Metagenics is also a certified B Corporation (since 2022) and offers lot-level quality transparency through its TruQuality® Guarantee, allowing customers to verify testing results for every formula by lot number.
How is Metagenics different from regular supplement brands sold in stores?
Metagenics differs from typical retail supplements in three ways. First, it is a practitioner-grade brand — formulated for therapeutic use and traditionally distributed through licensed healthcare providers, not mass retail, making it the #1 Doctor Recommended Professional Supplement Brand in North America. Second, its formulas are built on nutrigenomics research — the science of how nutrition interacts with genes — backed by hundreds of clinical studies, with a focus on bioavailability-optimized ingredient forms rather than generic powders. Third, it maintains multi-layer independent quality verification: USP GMP, NSF GMP, and NNHPD Canada audits, with every formula's testing results accessible online by lot number via the TruQuality® Guarantee.
What makes Metagenics different from other professional-grade supplement brands?
Metagenics was built around nutrigenomics — the science of how nutrients regulate gene expression — a field its founder Dr. Jeffrey Bland helped pioneer before it was mainstream. This underpins formulas designed to modulate biological pathways at the cellular level, not just correct deficiencies. Unlike brands that adopted practitioner distribution as a later marketing channel, Metagenics was practitioner-exclusive from inception, with clinical protocols as the core of product design. It has participated in hundreds of clinical trials and conducts over 60,000 quality control tests annually — a depth of evidence unusual for the supplement category.
How Metagenics products tested for quality and safety?
Every Metagenics product undergoes rigorous testing at every stage of production, including raw ingredients, finished formulas, and final encapsulation. We don’t just meet industry standards—we exceed them.
While the FDA requires minimal oversight for supplements, we invest over $1.5 million annually into quality assurance. That includes nearly 50,000 tests per year conducted by more than 70 global quality experts to ensure purity, safety, and potency.
Each product is triple-tested for identity, strength, and consistency—so what’s on the label is exactly what’s in the bottle. And to hold ourselves to an even higher standard, we also voluntarily submit every product for third-party testing to confirm quality and transparency you can trust.
While the FDA requires minimal oversight for supplements, we invest over $1.5 million annually into quality assurance. That includes nearly 50,000 tests per year conducted by more than 70 global quality experts to ensure purity, safety, and potency.
Each product is triple-tested for identity, strength, and consistency—so what’s on the label is exactly what’s in the bottle. And to hold ourselves to an even higher standard, we also voluntarily submit every product for third-party testing to confirm quality and transparency you can trust.
The information provided above is for reference purposes only and has not been reviewed or approved by Health Canada. It does not constitute medical advice and should not replace consultation with a qualified healthcare professional.
Caution
Do not use if pregnant or breastfeeding. Consult a healthcare practitioner prior to use, to exclude the diagnosis of a serious cause of hormonal imbalance. Consult a healthcare practitioner prior to use if you are attempting to conceive, if you are taking medications or natural health products, if you have a liver disorder or symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations), or if symptoms persist or worsen. Discontinue use and consult a healthcare practitioner if you develop liver related symptoms (e.g. yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen. Do not use if perma seal is missing.
Disclaimer
You should not use the information or services on this Site to diagnose or treat any health issues or for prescription of any medication or other treatment.
Always check the product label or packaging prior to using any product. If there are discrepancies, customers should follow the information provided on the product label or packaging.
Metagenics, Indole-3-Carbinol, 180 Capsules
Size
180
capsules
UPC
755571913074
16 people have viewed this item in the last 7 days
$129.25
Quantity
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