Designs for Health’s Calcium D-Glucarate features 150 mg of calcium from 1200 mg of calcium D-glucarate per 2-capsule serving to support the maintenance of good health. Calcium D-glucarate consists of elemental calcium bound to D-glucaric acid, which is produced in small amounts by the human body and is also found in various plant foods, such as apples, oranges, grapefruit, broccoli, cabbage, and kale. Some individuals may benefit from higher amounts of calcium D-glucarate through supplementation.
Calcium D-glucarate may help support the body’s ability to properly eliminate toxins and hormones by supporting liver detoxification capacity. A liver detoxification process called glucuronidation readily eliminates foreign toxins, such as environmental pollutants or pharmaceutical drugs, and excess hormones produced in the body, such as estrogen, testosterone, cortisol, and more. During glucuronidation, toxins and hormones become bound to glucuronic acid and are able to be eliminated from the body.
Elimination of the bound glucuronic acid compounds occurs through the stool in the gastrointestinal tract. Unfortunately, certain bacterial species located in the large intestine secrete an enzyme called β-glucuronidase that is capable of de-coupling or unbinding these compounds from glucuronic acid. This may impact the body’s ability to eliminate the compounds. In the body, calcium D-glucarate may potentially inhibit the activity of this enzyme, thereby facilitating the removal of these compounds. Reduction of this enzyme may also support increased excretion of bile acids and glucuronidation of cholesterol to promote healthy cholesterol metabolism and excretion.
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