• 300 mg of tocotrienols per softgel (90% delta, 10% gamma) with no tocopherols, to maximize tocotrienol benefits.
• Sourced from the annatto tree—the richest natural source of tocotrienols—with a 100% tocotrienol formulation and no tocopherols.
• Tocotrienols offer tissue-specific benefits across the body, supporting cardiovascular health and a healthy inflammatory response.
• Designed to avoid alpha-tocopherol interference, ensuring tocotrienol actions aren’t dampened.
Popular Searches
Top Brands
Available in store
Designs For Health, Annatto-E, 300, 30 Softgels
Size
30
softgels
UPC
879452005259
Best Before
01/2029
33 people have viewed this item in the last 7 days
About this item
Suggested Use
Adults: Take one softgel per day, or as directed by your health care practitioner. For use beyond 12 weeks, consult a healthcare practitioner.
Ingredients
Each softgel contains:
Tocotrienols (delta-tocotrienol 90%, gamma-tocotrienol 10%) (Bixa orellana-Seed)
300
mg
Non-medical Ingredients:
Gelatin, purified water, glycerine.
Description
Vitamin E consists of eight forms within two categories (tocotrienols and tocopherols). There are also four different tocotrienols and four different tocopherols. Each form has a slightly different structure and imparts unique properties that influence its function and effects on the body.
Annatto-E™ 300 is a unique tocopherol-free, tocotrienols-only product, featuring tocotrienols sourced from the annatto tree. Annatto is the richest known source of tocotrienols, containing 100% tocotrienols (90% delta and 10% gamma isomers), with no tocopherols. Annatto-E™ 300 contains 300 mg per softgel of delta/gamma tocotrienols. Commercial vitamin E supplements are typically rich in tocopherols and low or absent in tocotrienols; however, tocotrienol fractions have unique beneficial effects across a variety of tissues that make them desirable for supporting many aspects of health. Research indicates that tocopherols; especially alpha-tocopherol, may interfere with key therapeutic effects of tocotrienols, so it may be best to dose tocotrienols alone, without tocopherols.
- Supports vitamin E status
- Promotes metabolic and cardiovascular health
- Supports antioxidant status and a healthy inflammatory response
- Supports lung, skin, and eye health
- Supports healthy bones
Frequently Asked Questions
What is Designs for Health Annatto-E 300 and what is it used for?
Designs for Health Annatto-E 300 is a unique vitamin E supplement providing 300mg of tocotrienols per softgel — specifically 90% delta-tocotrienol and 10% gamma-tocotrienol — derived exclusively from annatto seeds, with zero tocopherols. Unlike conventional vitamin E supplements which are predominantly alpha-tocopherol, Annatto-E 300 delivers only the tocotrienol fraction of vitamin E. Tocotrienols have distinct biological activities from tocopherols, with research supporting their roles in cardiovascular health, antioxidant protection, anti-inflammatory response, and support for lung, skin, eye, bone, and cholesterol health.
What are tocotrienols and how do they differ from regular vitamin E (tocopherols)?
Vitamin E is a family of eight compounds: four tocotrienols (alpha, beta, gamma, delta) and four tocopherols (alpha, beta, gamma, delta). Most vitamin E supplements contain primarily alpha-tocopherol. Tocotrienols have an unsaturated side chain (three double bonds vs. the saturated side chain of tocopherols), which allows them to move more rapidly within cell membranes and penetrate tissues such as the brain and liver more effectively. Delta-tocotrienol (90% of this formula) is the most potently studied form for cholesterol regulation and anti-inflammatory pathways. Research also shows that alpha-tocopherol can compete with tocotrienols for cellular uptake receptors, potentially blunting tocotrienol benefits — this is why Annatto-E 300 is deliberately tocopherol-free.
Who should take Designs for Health Annatto-E 300 and how is it used?
Intended for adults under healthcare practitioner guidance who want tocotrienol-specific vitamin E activity, particularly those focused on cardiovascular health, cholesterol management, or anti-inflammatory support where tocotrienols show distinct research benefits. Take 1 softgel daily, or as directed by a healthcare provider. For use beyond 12 weeks, consult a healthcare practitioner. This product should not be combined with additional alpha-tocopherol supplements, as alpha-tocopherol may interfere with tocotrienol activity. Not recommended during pregnancy without medical supervision. Designs for Health products are available through licensed healthcare practitioners.
What makes Designs for Health Annatto-E 300 stand out among vitamin E supplements?
Annatto-E 300 is one of very few vitamin E supplements that is completely free of tocopherols, delivering only the tocotrienol fraction at a high dose of 300mg. Annatto (Bixa orellana) is the richest known natural source of tocotrienols, providing 100% tocotrienols with no tocopherols — unlike palm oil (a common tocotrienol source) which naturally contains both. The tocopherol-free design is clinically intentional: research published by Barrie Tan, PhD (the scientist most associated with delta-tocotrienol research) shows that alpha-tocopherol supplementation reduces the bioavailability of tocotrienols. Designs for Health is ranked the most trusted supplement brand by functional medicine practitioners in a 2023 IPSOS survey of North American practitioners.
What is Designs for Health, and is it trusted by medical professionals?
Designs for Health is a practitioner-exclusive supplement brand founded in 1989, guided by a Science-First philosophy. According to an IPSOS 2023 independent survey, it is the number one practitioner supplement brand both recommended by and personally trusted by functional medicine professionals in North America. Products are formulated with meaningful, research-validated quantities of functional ingredients and distributed exclusively through licensed healthcare practitioners -- not available in retail stores.
How does Designs for Health differ from other practitioner supplement brands?
Designs for Health's distinguishing factor is its validated standing among functional medicine professionals specifically -- not just naturopaths or general practitioners. The IPSOS 2023 survey measured the brand practitioners 'personally trust' (not just prescribe), a distinction that reflects genuine confidence rather than sales channel access. The brand also runs the accredited Dietary Supplement Specialist (DSS) Certification Program for healthcare professionals, recognizing that many practitioners lack formal training in supplement science. This investment in practitioner education -- rather than just product sales -- is uncommon in the category and builds a different type of professional relationship.
The information provided above is for reference purposes only and has not been reviewed or approved by Health Canada. It does not constitute medical advice and should not replace consultation with a qualified healthcare professional.
Disclaimer
You should not use the information or services on this Site to diagnose or treat any health issues or for prescription of any medication or other treatment.
Always check the product label or packaging prior to using any product. If there are discrepancies, customers should follow the information provided on the product label or packaging.
Designs For Health, Annatto-E, 300, 30 Softgels
Size
30
softgels
UPC
879452005259
Best Before
01/2029
33 people have viewed this item in the last 7 days
Note: As required by the manufacturer, to see the price and purchase this
product
you need to log in first.
In-Store Purchases
In stock at LIFEPLUS Natural Health
#1825 - 4720 Mcclelland Rd, Richmond, BC
Free in-store pickup available
Ready by
Today, Aug 18
⏱️
Shipping Options
Available to ship
Estimate Ship Date
Today, Aug 18
⏱️
Metro Vancouver
Free Shipping Over $69
Within Canada
Free Shipping Over $99
United States
Mainland China
Starting from $9
Note
Due to the nature of this item, we cannot accept any returns.
Click for more information >>
Click for more information >>
